Review of various studies indicated that there is strong association between higher cholesterol levels in the elderly with lower risk of non-cardiovascular disease and total mortality. Lower cholesterol levels have been strongly associated with higher all cause mortality and is utilized as a measure of "frailty" in the elderly. A large study of over 19,000 individuals, aged 65-82, found relative risk reduction of all cause mortality of 22% in statin therapy users vs. non-users. There was also associated protective value of statin therapy against dementia for the "middle aged" but on the flip side there was a notable increase in cognitive issues in the elderly utilizing this therapy. Additionally at older ages there are strong adverse issues related to individuals with fall histories, increased incidences of depression, symptoms of intolerance (muscle aches and gastric symptomology), and significant concerns related to poly-pharmacology.
As with most studies on the subject, there are pros/cons related to the use of this therapy. Not quite the "wonder drug" touted by some, especially in our aging population. As with any therapy, "one size does not fit all " and caution should be utilized when assessing mortality risk (or improvement) when it comes to statin therapy and the elderly!
"I find that a great part of the information I have was acquired by looking up something and finding something else on the way"
Franklin P. Adams (1181-1960)
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